ABSTRACT
Statement of Problem: Oral lichen planus [OLP] is a chronic inflammatory oral mucosal disease with indefinite etiology. In recent researches, free radicals have been deliberated as the possible etiology of inflammatory and autoimmune diseases
Purpose: This study was aimed to evaluate the stress oxidative status with the nitric oxide [NO] index in a sample of Iranian population
Materials and Method: In this descriptive-comparative study, serum NO level was assessed in 20 OLP patients as the case group and 20 healthy individuals as the control group. Collected data were analyzed by adopting two Sample t-test, using SPSS 16 software. The statistical significance level was set at p< 0.05
Results: The mean serum NO levels in OLP patients and healthy controls were 17.1 +/- 3.4 ng/ml and 14.5 +/- 2.7 ng/ml respectively; which revealed a significant statistical difference [p= 0.009]
Conclusion: The results of the current study with its limitation may support the premise that higher serum levels of NO in patients with OLP might activate the process of lymphocytes and cellular immunity system; hence, possibly endorsing the effect of serum NO in pathogenesis of lichen planus
ABSTRACT
Statement of Problem: Lichen planus is a chronic inflammatory immunologic-based disease involving skin and mucosa. This disease is generally divided into two categories: erosive and non-erosive. Many etiologic factors are deliberated regarding the disease; however, the disorders of immune system and the role of cytotoxic T-lymphocytes and monocytes are more highlighted. Zinc is an imperative element for the growth of epithelium and its deficiency induces the cytotoxic activity of T-helper2 cells, which seems to be associated with lichen planus
Purpose: This study was aimed to evaluate the levels of serum zinc in erosive and non-erosive oral lichen planus [OLP] and to compare it with the healthy control group to find out any feasible inference
Materials and Method: A total of 22 patients with erosive oral lichen planus, 22 patients with non erosive OLP and 44 healthy individuals as the control group were recruited in this descriptive-comparative study. All the participants were selected from the referees to the department of oral medicine, school of dentistry, Tabriz University of Medical Sciences. Serum zinc level was examined for all the individuals with liquid-stat kit [Beckman Instruments Inc.; Carlsbad, CA]. Data were analyzed by adopting the ANOVA and Tukey tests, using SPSS 16 statistical software
Results: The mean age of patients with erosive and non-erosive LP was 41.7 and 41.3 years, respectively. The mean age of the healthy control group was 34.4 years .The mean serum zinc levels in the erosive and non erosive lichen planus groups and control groups were 8.3 [1.15], 11.15 [0.92] and 15.74 [1.75] micro g/dl respectively. The difference was statistically significant [p< 0.05]
Conclusion: The serum zinc levels were decreased in patients with erosive oral lichen planus. This finding may probably indicate the promising role of zinc in development of oral lichen planus
ABSTRACT
Erosion is a multi-factorial process that occurs during life and it happens by many external or internal factors. The current study aimed to evaluate the relation of swimming time and dental erosion among swimmers. In this descriptive-analytical study, 84women individuals were selected. The case group included 42 swimmers who swam more than 6 hours per week and the control group comprised of 42 swimmers who swam less than 6 hours. The information regarding dental erosions and other data was collected by questionnaires. The dental erosion evaluation was performed using Smith-Knight index. X[2] was utilized for statistical comparisons. The P-value of less than 0.05 was considered statistically significant. Findings revealed that the dental erosion proportions was similar among two groups and there was no relation between swimming time and dental erosion among swimmers [p-value= 0/6, X[2] 0.26]. There was no relation between swimming time and dental erosion among swimmers. Therefore, the role of swimming time on dental erosion was not proved
ABSTRACT
Patients undergoing high-dose chemotherapy for hematological malignancies are susceptible to development of oral mucositis, and no effective modality has been reported for its prophylaxis and treatment. The aim of this study was to evaluate the effectiveness of zinc mouthwash on chemotherapy-induced oral mucositis lesions. In this double-blind randomized trial, patients under chemotherapy for acute leukemia were divided into two test and control groups of 15 patients each. The groups were homogeneous with respect to medical history, tumor characteristics, and therapeutic details. The test group received 10ml 0.2% zinc sulfate mouthwash, and the control group received 10ml 0.2% chlorhexidine gluconate mouthwash, twice a day for a period of two weeks. Spijkervet scale was used to grade the severity of mucositis at every other week during eight weeks. The severity scores were analyzed with repeated measure ANOVA using SPSS 13.0 computer software. Mean severity scores were generally lower in the test group compared to the controls at all four time intervals evaluated; but only, the differences in weeks of 2 and 3 were statistically significant [P=0.025]. Zinc mouthwash used in conjunction with chemotherapy may reduce the severity of oral mucositis lesions in patients with leukaemia